Intensidad regional en el carcinoma in situ de la mama en el tratamiento conservador.
Association of Regional Intensity of Ductal Carcinoma In Situ Treatment With Likelihood of Breast Preservation.
Punglia, R.S.; Cronin, A.M.; Uno, H.; Stout, N.K.; Ozanne, E.M.; Greenberg, C.C.; Frank, E.S.; Schrag, D.
Vol. 3 Nr. 1 Página: 101 - 104 Fecha de publicación: 01/01/2017
Resumen:
Importance: Large regional variation exists in the use of radiotherapy after breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS). Although patients who do not receive initial radiotherapy for DCIS are candidates for subsequent BCS if they experience a second breast event, many undergo mastectomy instead. Objective: To examine whether regional practice patterns of radiotherapy for DCIS affect the use of mastectomy in these patients. Design, Setting, and Participants: A retrospective analysis of population-based databases (Surveillance, Epidemiology, and End Results [SEER] and SEER-Medicare). Data were obtained for 2679 women in SEER with a diagnosis of DCIS between 1990 and 2011 and for 757 women in SEER-Medicare with a DCIS diagnosis between 1991 and 2009 who had not undergone radiotherapy for DCIS and experienced a subsequent breast cancer or DCIS diagnosis. Exposures: Treatment intensity for primary DCIS (high, medium, low), as defined by separating health service areas (HSAs) into 3 clusters based on radiotherapy use. Main Outcomes and Measures: Mastectomy vs BCS at a second breast event defined as DCIS recurrence or new invasive cancer. Results: The median (SD) ages of the participants was 64 (13) years for the 2679 SEER population and 79 (6) years for the SEER-Medicare cohort. Residence in an HSA characterized by greater radiotherapy use for DCIS increased the likelihood of receiving mastectomy vs BCS at a subsequent breast event, even among women who had not previously received radiotherapy for DCIS. Adjusted odds ratios for receiving mastectomy were 1.43 (95% CI, 1.10-1.85) and 1.90 (95% CI, 1.27-2.84) in SEER and SEER-Medicare databases, respectively, among women residing in an HSA with the greatest radiotherapy use vs the least, corresponding to an adjusted increase from 40.8% to 49.6%, and from 38.6% to 54.5%. Conclusions and Relevance: Areas with more radiotherapy use for DCIS had increased use of mastectomy at the time of a second breast event even among patients eligible for breast conservation. This association suggests that physician-related factors are affecting the likelihood of breast preservation.
Acceda al artículo completo aquí: https://www.ncbi.nlm.nih.gov/pubmed/?term=Association+of+Regional+Intensity+of+Ductal+Carcinoma+In+Situ+Treatment+With+Likelihood+of+Breast+Preservation
